Cardiovascular Genetics: A News Round-Up
نویسنده
چکیده
481 1. Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012;485:593–598. 2. Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature. 2012;485:599–604.
منابع مشابه
Cardiovascular Genetics: A News Round Up Summary of Recent Articles of Interest
How Was the Hypothesis Tested? The authors performed a genome-wide linkage analysis and subsequent fine mapping in a family with 11 affected members to identify a chromosomal locus segregating with the condition. Then, candidate genes in the critical region were sequenced and biochemical analyses as well as animal experiments were performed to assess the biological consequences of the detected ...
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Principal Findings The authors identified mutations in almost half of children without a positive family history of cardiomyopathy (25 of 51 affected children) and in two thirds (21 of 33) of affected children with familial cardiomyopathy. Mutations in MYH7 (encoding -myosin heavy chain) and MYBPC3 (encoding myosin-binding protein C) were the most frequent variants identified in the children. I...
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Study Hypothesis Initial genome-wide association studies (GWAS) for hypertension, a common cardiovascular risk factor, have delivered unexpectedly few and modest associations. The authors of the International Consortium for Blood Pressure Genome-Wide Association Studies set out to identify novel genetic variants in relation to blood pressure, intermediate phenotypes, and cardiovascular disease ...
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Principal Findings The authors identified mutations in almost half of children without a positive family history of cardiomyopathy (25 of 51 affected children) and in two thirds (21 of 33) of affected children with familial cardiomyopathy. Mutations in MYH7 (encoding -myosin heavy chain) and MYBPC3 (encoding myosin-binding protein C) were the most frequent variants identified in the children. I...
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Study Hypothesis African Americans have much higher rates of kidney failure than those of European ancestry. Previous genetic studies found variation at or near the MYH9 gene to be associated with increased risk of focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD), but the causal mutations in MYH9 were not identified. The authors hypothesize...
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